Liver X receptor alpha

NR1H3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1UHL, 3IPQ, 3IPS, 3IPU, 5AVI, 5AVL, 5HJS

Identifiers

Aliases

NR1H3, LXR-a, LXRA, RLD-1, Liver X receptor alpha, nuclear receptor subfamily 1 group H member 3

External IDs

MGI: 1352462 HomoloGene: 21165 GeneCards: NR1H3

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	No data available	Start	47,248,300 bp
Band	No data available	End	47,269,032 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	No data available	Start	91,184,061 bp
Band	No data available	End	91,202,834 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• cholesterol binding • protein binding • zinc ion binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • sterol response element binding • steroid hormone receptor activity • transcription coactivator activity • DNA binding • sequence-specific DNA binding • metal ion binding • transcription regulatory region DNA binding • transcription factor activity, sequence-specific DNA binding
Cellular component	• nuclear chromatin • receptor complex • nucleoplasm • RNA polymerase II transcription factor complex • nucleus
Biological process	• positive regulation of toll-like receptor 4 signaling pathway • positive regulation of receptor biosynthetic process • sterol homeostasis • negative regulation of pancreatic juice secretion • negative regulation of inflammatory response • cellular response to lipopolysaccharide • regulation of cholesterol homeostasis • negative regulation of lipid transport • positive regulation of lipoprotein lipase activity • lipid homeostasis • triglyceride homeostasis • positive regulation of cholesterol homeostasis • negative regulation of macrophage activation • negative regulation of macrophage derived foam cell differentiation • positive regulation of cholesterol transport • negative regulation of cholesterol storage • regulation of transcription, DNA-templated • positive regulation of triglyceride biosynthetic process • positive regulation of cholesterol efflux • positive regulation of cellular protein metabolic process • negative regulation of interferon-gamma-mediated signaling pathway • regulation of circadian rhythm • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • response to progesterone • steroid hormone mediated signaling pathway • cholesterol homeostasis • apoptotic cell clearance • positive regulation of fatty acid biosynthetic process • transcription initiation from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • negative regulation of secretion of lysosomal enzymes • negative regulation of pinocytosis • positive regulation of transcription, DNA-templated • intracellular receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10062


22259

Ensembl


ENSG00000025434


ENSMUSG00000002108

UniProt


Q13133


Q9Z0Y9

RefSeq (mRNA)


NM_001130101 NM_001130102 NM_001251934 NM_001251935 NM_005693


NM_001177730 NM_013839

RefSeq (protein)

NP_001123573 NP_001123574 NP_001238863 NP_001238864 NP_005684
NP_005684.2


NP_001171201 NP_038867

Location (UCSC)

Chr 11: 47.25 – 47.27 Mb

Chr 11: 91.18 – 91.2 Mb

PubMed search

1UHL, 3IPQ, 3IPS, 3IPU, 5AVI, 5AVL, 5HJS

NM_001130101
NM_001130102
NM_001251934
NM_001251935
NM_005693

NM_001177730
NM_013839

NP_005684.2

NP_001171201
NP_038867

...
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