List of second-generation Major League Baseball players

The following is a list of father-and-son combinations who have played or managed in Major League Baseball (MLB).

Jack Doscher, son of Herm Doscher, became the first second-generation MLB player when he made his debut in 1903.

Ken Griffey, Sr. and Ken Griffey, Jr. became the first father-and-son combination to play in Major League Baseball at the same time, in 1989 when Ken, Jr. was called up by the Seattle Mariners while Ken, Sr. was playing with the Cincinnati Reds. They became Mariner teammates in 1990. In Ken, Sr.'s first game as a Mariner, on August 31, 1990, the pair hit back-to-back singles in the first inning and both scored. On September 14, in the top of the first off California Angels pitcher Kirk McCaskill, the pair hit back-to-back home runs, becoming the first and only father-son duo to ever accomplish such a feat. The duo played a total of 51 games together before Griffey, Sr., retired in June 1991.

In 2001, Tim Raines and Tim Raines, Jr. also played as teammates with the Baltimore Orioles.

Cecil and Prince Fielder are the only father-son combination each to hit 50 or more home runs in any season. Cecil Fielder hit 51 homers in 1990. Seventeen years later, his son, Prince, hit 50.

Three families have had a father and son serve as manager: the Macks (Connie and Earle), the Sislers (George and Dick) and the Skinners (Bob and Joel).

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