Leland B. Harrison (25 April 1883, in New York City – 6 June 1951, in Washington D.C.), was a United States diplomat. The son of W. Henry Harrison and Helen (Skidmore) Harrison.
He was educated at Eton College, Harvard College, and Harvard Law School. After law school, Harrison became the private secretary of United States Ambassador to Japan Thomas J. O'Brien. He was appointed Third Secretary of the U.S. Embassy in Tokyo on June 10, 1908. He later filled posts in the United States embassies in Peking, London, and Bogotá. In 1918, he became diplomatic secretary of the American Commission to Negotiate Peace. He later became counselor of the U.S. Embassy in Paris.
In 1916 President Woodrow Wilson allowed Secretary of State Robert Lansing and Frank Polk quietly and informally to channel the flow of military and law enforcement material into the State Department's Bureau of Secret Intelligence (U-1), what is now known as the Diplomatic Security Service. The two men picked Leland Harrison "to take charge of the collection and examination of all information of a secret nature coming into the Department from various sources and also to direct the work of the agents specially employed for that purpose."