Lecithin-cholesterol acyltransferase

LCAT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X96, 4XWG, 4XX1, 5BV7
Identifiers
Aliases	LCAT, entrez:3931, lecithin-cholesterol acyltransferase
External IDs	OMIM: 606967 MGI: 96755 HomoloGene: 68042 GeneCards: LCAT
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 67,939,750 bp End 67,944,131 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 D3|8 53.06 cM Start 105,939,551 bp End 105,943,382 bp
Gene ontology Molecular function • transferase activity • O-acyltransferase activity • apolipoprotein A-I binding • protein binding • transferase activity, transferring acyl groups • phosphatidylcholine-sterol O-acyltransferase activity Cellular component • extracellular region • high-density lipoprotein particle • extracellular exosome • extracellular space Biological process • steroid metabolic process • regulation of high-density lipoprotein particle assembly • lipid metabolic process • cholesterol transport • cholesterol metabolic process • cholesterol esterification • very-low-density lipoprotein particle remodeling • phospholipid metabolic process • lipoprotein biosynthetic process • cholesterol homeostasis • phosphatidylcholine biosynthetic process • phosphatidylcholine metabolic process • reverse cholesterol transport • high-density lipoprotein particle remodeling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3931	16816
Ensembl	ENSG00000213398	ENSMUSG00000035237
UniProt	P04180	P16301
RefSeq (mRNA)	NM_000229	NM_008490
RefSeq (protein)	NP_000220	NP_032516
Location (UCSC)	Chr 16: 67.94 – 67.94 Mb	Chr 8: 105.94 – 105.94 Mb
PubMed search

4X96, 4XWG, 4XX1, 5BV7

3931

16816

ENSG00000213398

ENSMUSG00000035237

P04180

P16301

NM_000229

NM_008490

NP_000220

NP_032516

Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma.LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage.

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Wikipedia