Lawrence Michael DeFalco (August 25, 1915 – September 22, 1979) was an American prelate of the Roman Catholic Church. He served as Bishop of Amarillo from 1963 to 1979.
The eldest of nine children, Lawrence DeFalco was born in McKeesport, Pennsylvania, to Rosario and Margret (née Desmone) DeFalco. His father was originally from Atena Lucana, Italy and worked as a streetcar company foreman. He entered St. Vincent's College at Latrobe in 1933. However, he was forced to enter St. John's Home Mission Seminary at Little Rock, Arkansas, in 1935, because the Diocese of Pittsburgh to the Great Depression. He was ordained to the priesthood on June 11, 1942.
DeFalco then served as a curate at St. Patrick's Cathedral in Fort Worth, Texas, until 1952, when he became vice-chancellor of the Diocese of Dallas-Fort Worth. He briefly served as a curate at Sacred Heart Cathedral in Dallas before being sent in 1953 to study at the Pontifical Gregorian University in Rome, from where he obtained a Licentiate of Canon Law. Following his return to Dallas in 1955, he became secretary of the diocesan marriage tribunal. He served as the founding pastor of Our Lady of Perpetual Help in Dallas from 1956 to 1962. He was named a Papal Chamberlain in 1961, and rector of St. Patrick Cathedral at Fort Worth in 1962.