Large neutral amino acid transporter
| solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport) | |
|---|---|
| Identifiers | |
| Symbol | SLC3A2 |
| Alt. symbols | MDU1, 4T2HC, 4F2, NACAE, CD98 |
| Entrez | 6520 |
| HUGO | 11026 |
| OMIM | 158070 |
| RefSeq | NM_001013251 |
| UniProt | P08195 |
| Other data | |
| Locus | Chr. 11 q12-q22 |
| solute carrier family 7 member 5 (cationic amino acid transporter, y+ system) | |
|---|---|
| Identifiers | |
| Symbol | SLC7A5 |
| Alt. symbols | LAT1, E16, D16S469E, MPE16, CD98 |
| Entrez | 8140 |
| HUGO | 11063 |
| OMIM | 600182 |
| RefSeq | NM_003486 |
| UniProt | Q01650 |
| Other data | |
| Locus | Chr. 16 q24.3 |
CD98 is a glycoprotein that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids. LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
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