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Largactil

Chlorpromazine
Skeletal formula of chlorpromazine
Ball-and-stick model of the chlorpromazine molecule
Clinical data
Trade names Largactil, Thorazine, others
AHFS/Drugs.com Monograph
MedlinePlus a682040
License data
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
administration
Oral (tablets and syrup available), rectal, IM, IV infusion
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 10–80% (Oral; large interindividual variation)
Protein binding 90–99%
Metabolism Liver, mostly CYP2D6-mediated
Biological half-life 30 hours
Excretion Urine (43–65% in 24 hrs)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.000.042
Chemical and physical data
Formula C17H19ClN2S
Molar mass 318.86 g/mol (free base)
355.33 g/mol (hydrochloride)
3D model (Jmol)
  

Chlorpromazine (CPZ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given by mouth, by injection into a muscle, or into a vein.

Common side effects include movement problems, sleepiness, dry mouth, low blood pressure upon standing, and increased weight. Serious side effects may include the potentially permanent movement disorder tardive dyskinesia, neuroleptic malignant syndrome, and low white blood cell levels. In older people with psychosis as a result of dementia it may increase the risk of dying. It is unclear if it is safe for use in pregnancy. Chlorpromazine is in the typical antipsychotic class. Its mechanism of action is not entirely clear but believed to be related to its ability as a dopamine antagonist. It also has anti-serotonergic and antihistaminergic properties.


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