Lake Centre was a federal electoral district in Saskatchewan, Canada, that was represented in the Canadian House of Commons from 1935 to 1953. This riding was created in 1933 from parts of Last Mountain, Long Lake and Regina ridings.
From 1940 to 1952, the seat was held by John Diefenbaker, who later served as Prime Minister of Canada.
It was abolished in 1952 when it was redistributed into Melville, Moose Jaw—Lake Centre, Rosetown—Biggar and Yorkton ridings.