Lactoperoxidase

LPO
Identifiers
Aliases	LPO, SPO, lactoperoxidase
External IDs	MGI: 1923363 HomoloGene: 21240 GeneCards: LPO
Gene ontology Molecular function • thiocyanate peroxidase activity • oxidoreductase activity • heme binding • metal ion binding • peroxidase activity Cellular component • extracellular region • basolateral plasma membrane • extracellular exosome • extracellular space • cytoplasm Biological process • cellular oxidant detoxification • defense response to bacterium • detection of chemical stimulus involved in sensory perception of bitter taste • response to oxidative stress • oxidation-reduction process • hydrogen peroxide catabolic process • thiocyanate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4025	76113
Ensembl	ENSG00000167419	ENSMUSG00000009356
UniProt	P22079	n/a
RefSeq (mRNA)	NM_001160102 NM_006151	NM_080420
RefSeq (protein)	NP_001153574 NP_006142	n/a
Location (UCSC)	Chr 17: 58.22 – 58.27 Mb	Chr 11: 87.81 – 87.83 Mb
PubMed search

4025

76113

ENSG00000167419

ENSMUSG00000009356

P22079

n/a

NM_001160102
NM_006151

NM_080420

NP_001153574
NP_006142

n/a

Lactoperoxidase is a peroxidase enzyme secreted from mammary, salivary, and other mucosal glands that functions as a natural antibacterial agent. Lactoperoxidase is a member of the heme peroxidase family of enzymes. In humans, lactoperoxidase is encoded by the LPO gene.

Lactoperoxidase catalyzes the oxidation of a number of inorganic and organic substrates by hydrogen peroxide. These substrates include bromide and iodide and therefore lactoperoxidase can be categorised as a haloperoxidase. Another important substrate is thiocyanate. The oxidized products produced through the action of this enzyme have potent bactericidal activities. Lactoperoxidase together with its inorganic ion substrates, hydrogen peroxide, and oxidized products is known as the lactoperoxidase system.

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