LTBP2

LTBP2
Identifiers
Aliases	LTBP2, C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3, latent transforming growth factor beta binding protein 2
External IDs	MGI: 99502 HomoloGene: 369 GeneCards: LTBP2
Gene ontology Molecular function • calcium ion binding • heparin binding • protein binding • growth factor binding Cellular component • extracellular matrix • extracellular region • extracellular exosome • intracellular • proteinaceous extracellular matrix • extracellular space Biological process • protein targeting • transforming growth factor beta receptor signaling pathway • protein secretion • supramolecular fiber organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4053	16997
Ensembl	ENSG00000119681	ENSMUSG00000002020
UniProt	Q14767	O08999
RefSeq (mRNA)	NM_000428	NM_013589
RefSeq (protein)	NP_000419	NP_038617.3 NP_038617
Location (UCSC)	Chr 14: 74.5 – 74.61 Mb	Chr 12: 84.78 – 84.88 Mb
PubMed search

4053

16997

ENSG00000119681

ENSMUSG00000002020

Q14767

O08999

NM_000428

NM_013589

NP_000419

NP_038617.3
NP_038617

Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.

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