LSD-25
2D structural formula and 3D models of LSD
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| Clinical data | |
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| Pronunciation | /daɪ eθəl ˈæmaɪd/, /æmɪd/, or /eɪmaɪd/) |
| AHFS/Drugs.com | Reference |
| Pregnancy category |
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| Dependence liability |
Low |
| Addiction liability |
None |
| Routes of administration |
Oral, sublingual, intravenous, ocular, intramuscular |
| Drug class | Psychedelic; Serotonergic psychedelic |
| ATC code |
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| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 71% |
| Protein binding | Unknown |
| Metabolism | Hepatic () |
| Metabolites | 2-Oxo-3-hydroxy-LSD |
| Onset of action | 30–40 minutes |
| Biological half-life | 3.6 hours |
| Duration of action | 8–12 hours |
| Excretion | Renal |
| Identifiers | |
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| Synonyms | Lyserg-säure-diäthylamid; LSD; LSD-25; Lysergide; Acid; Delysid |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| ChEBI | |
| ChEMBL | |
| PDB ligand | |
| ECHA InfoCard | 100.000.031 |
| Chemical and physical data | |
| Formula | C20H25N3O |
| Molar mass | 323.44 g·mol−1 |
| 3D model (Jmol) | |
| Melting point | 80 to 85 °C (176 to 185 °F) |
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Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects. This may include altered awareness of the surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not. It is used mainly as a recreational drug and for spiritual reasons. LSD is typically either swallowed or held under the tongue. It is often sold on blotter paper, a sugar cube, or gelatin. It can also be injected.
LSD is not addictive. However, adverse psychiatric reactions such as anxiety, paranoia, and delusions are possible. LSD is in the ergoline family. LSD is sensitive to oxygen, ultraviolet light, and chlorine, though it may last for years if it is stored away from light and moisture at low temperature. In pure form it is odorless and clear or white in color. As little as 20–30 micrograms can produce an effect.
LSD was first made by Albert Hofmann in Switzerland in 1938 from ergotamine, a chemical from the fungus ergot. The laboratory name for the compound was the acronym for the German "Lyserg-säure-diäthylamid", followed by a sequential number: LSD-25. Hofmann discovered its psychedelic properties in 1943. LSD was introduced as a commercial medication under the trade-name Delysid for various psychiatric uses in 1947. In the 1950s, officials at the U.S. Central Intelligence Agency (CIA) thought the drug might be useful for mind control and chemical warfare and tested the drug on young servicemen and students, and others without their knowledge. The subsequent recreational use by youth culture in the Western world as part of 1960s counterculture resulted in its prohibition.
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