LPAR6

LPAR6
Identifiers
Aliases	LPAR6, ARWH1, HYPT8, LAH3, P2RY5, P2Y5, lysophosphatidic acid receptor 6
External IDs	MGI: 1914418 HomoloGene: 55925 GeneCards: LPAR6
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • lysophosphatidic acid receptor activity Cellular component • integral component of membrane • plasma membrane • membrane • integral component of plasma membrane • intracellular membrane-bounded organelle Biological process • G-protein coupled receptor signaling pathway • signal transduction • positive regulation of Rho protein signal transduction • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10161	67168
Ensembl	ENSG00000139679	ENSMUSG00000033446
UniProt	P43657	Q8BMC0
RefSeq (mRNA)	NM_005767 NM_001162497 NM_001162498	NM_175116
RefSeq (protein)	NP_001155969 NP_001155970 NP_005758	NP_780325
Location (UCSC)	Chr 13: 48.39 – 48.44 Mb	Chr 14: 73.24 – 73.24 Mb
PubMed search

10161

67168

ENSG00000139679

ENSMUSG00000033446

P43657

Q8BMC0

NM_005767
NM_001162497
NM_001162498

NM_175116

NP_001155969
NP_001155970
NP_005758

NP_780325

Lysophosphatidic acid receptor 6 also known as LPA₆, P2RY5, and GPR87, is a protein that in humans is encoded by the LPAR6 gene. LPA₆ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.

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