LPAR3

LPAR3
Identifiers
Aliases	LPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDs	MGI: 1929469 HomoloGene: 8123 GeneCards: LPAR3
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • lysophosphatidic acid receptor activity • G-protein alpha-subunit binding • phospholipid binding • lipid binding Cellular component • integral component of membrane • membrane • integral component of plasma membrane • axon • plasma membrane Biological process • chemical synaptic transmission • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • positive regulation of cytosolic calcium ion concentration • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • bleb assembly • positive regulation of collateral sprouting • activation of MAPK activity • signal transduction • positive regulation of MAPK cascade • positive regulation of calcium ion transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23566	65086
Ensembl	ENSG00000171517	ENSMUSG00000036832
UniProt	Q9UBY5	Q9EQ31
RefSeq (mRNA)	NM_012152	NM_022983
RefSeq (protein)	NP_036284	NP_075359.1 NP_075359
Location (UCSC)	Chr 1: 84.81 – 84.89 Mb	Chr 3: 146.22 – 146.29 Mb
PubMed search

23566

65086

ENSG00000171517

ENSMUSG00000036832

Q9UBY5

Q9EQ31

NM_012152

NM_022983

NP_036284

NP_075359.1
NP_075359

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein that in humans is encoded by the LPAR3 gene. LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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