LIG4

LIG4

Protein LIG4 PDB 1ik9.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1IK9, 2E2W, 3II6, 3VNN, 3W1B, 3W1G, 3W5O, 4HTO, 4HTP

Identifiers

LIG4, LIG4S, DNA ligase 4

External IDs

MGI: 1335098 HomoloGene: 1736 GeneCards: LIG4

Gene ontology
Molecular function	• nucleotide binding • metal ion binding • protein C-terminus binding • protein binding • ATP binding • DNA ligase (ATP) activity • ligase activity • DNA binding • DNA ligase activity
Cellular component	• focal adhesion • plasma membrane • nucleoplasm • DNA ligase IV complex • nonhomologous end joining complex • condensed chromosome • nuclear chromosome, telomeric region • nucleus • DNA-dependent protein kinase-DNA ligase 4 complex • cytoplasm • cytosol
Biological process	• nucleotide-excision repair, DNA gap filling • double-strand break repair via classical nonhomologous end joining • response to ionizing radiation • DNA recombination • lagging strand elongation • DNA biosynthetic process • cellular response to lithium ion • single strand break repair • cellular response to DNA damage stimulus • cell division • DNA replication • positive regulation of chromosome organization • establishment of integrated proviral latency • cell cycle • response to X-ray • positive regulation of neurogenesis • DNA ligation involved in DNA recombination • DNA ligation • DNA ligation involved in DNA repair • somatic stem cell population maintenance • chromosome organization • T cell receptor V(D)J recombination • neuron apoptotic process • isotype switching • T cell differentiation in thymus • central nervous system development • immunoglobulin V(D)J recombination • double-strand break repair via nonhomologous end joining • positive regulation of fibroblast proliferation • in utero embryonic development • cell proliferation • V(D)J recombination • pro-B cell differentiation • DNA repair • response to gamma radiation • double-strand break repair • negative regulation of neuron apoptotic process
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE LIG4 206235 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


3981


319583


ENSG00000174405


ENSMUSG00000049717


P49917


Q8BTF7

RefSeq (mRNA)

NM_001098268 NM_002312 NM_206937 NM_001330595 NM_001352598
NM_001352599 NM_001352600 NM_001352601 NM_001352602 NM_001352603 NM_001352604


NM_176953

RefSeq (protein)

NP_001091738 NP_001317524 NP_002303 NP_996820 NP_001339527
NP_001339528 NP_001339529 NP_001339530 NP_001339531 NP_001339532 NP_001339533


NP_795927

Location (UCSC)

Chr 13: 108.21 – 108.22 Mb

Chr 8: 9.97 – 9.98 Mb

PubMed search

1IK9, 2E2W, 3II6, 3VNN, 3W1B, 3W1G, 3W5O, 4HTO, 4HTP

ENSG00000174405

ENSMUSG00000049717

NM_001352599
NM_001352600
NM_001352601
NM_001352602
NM_001352603
NM_001352604

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Wikipedia

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