LIG3

LIG3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IMO, 1IN1, 1UW0, 3L2P, 3PC7, 3PC8, 3QVG
Identifiers
Aliases	LIG3, LIG2, DNA ligase 3
External IDs	MGI: 109152 HomoloGene: 32109 GeneCards: LIG3
Gene ontology Molecular function • DNA binding • nucleotide binding • zinc ion binding • metal ion binding • ligase activity • protein binding • DNA ligase activity • ATP binding • DNA ligase (ATP) activity Cellular component • DNA ligase III-XRCC1 complex • nucleoplasm • nucleus • mitochondrion Biological process • nucleotide-excision repair, DNA gap filling • DNA recombination • lagging strand elongation • DNA biosynthetic process • mitochondrial DNA repair • mitochondrion organization • double-strand break repair via alternative nonhomologous end joining • negative regulation of mitochondrial DNA replication • cellular response to DNA damage stimulus • cell division • DNA ligation • DNA replication • double-strand break repair via homologous recombination • V(D)J recombination • DNA ligation involved in DNA repair • cell cycle • transcription-coupled nucleotide-excision repair • double-strand break repair • DNA repair • base-excision repair, DNA ligation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3980	16882
Ensembl	ENSG00000005156	ENSMUSG00000020697
UniProt	P49916	P97386
RefSeq (mRNA)	NM_002311 NM_013975	NM_001291245 NM_001291246 NM_001291247 NM_010716
RefSeq (protein)	NP_002302 NP_039269	n/a
Location (UCSC)	Chr 17: 34.98 – 35.01 Mb	Chr 11: 82.78 – 82.8 Mb
PubMed search

1IMO, 1IN1, 1UW0, 3L2P, 3PC7, 3PC8, 3QVG

3980

16882

ENSG00000005156

ENSMUSG00000020697

P49916

P97386

NM_002311
NM_013975

NM_001291245
NM_001291246
NM_001291247
NM_010716

NP_002302
NP_039269

n/a

DNA ligase 3 is an enzyme that in humans is encoded by the LIG3 gene. The human LIG3 gene encodes ATP-dependent DNA ligases that seal interruptions in the phosphodiester backbone of duplex DNA.

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Wikipedia