LGR5

LGR5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BSR, 4BSS, 4BST, 4BSU, 4KNG, 4UFR, 4UFS
Identifiers
Aliases	LGR5, FEX, GPR49, GPR67, GRP49, HG38, leucine-rich repeat containing G protein-coupled receptor 5, leucine rich repeat containing G protein-coupled receptor 5
External IDs	MGI: 1341817 HomoloGene: 20807 GeneCards: LGR5
Gene ontology Molecular function • protein binding • G-protein coupled receptor activity • transmembrane signaling receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma membrane • Golgi apparatus • integral component of plasma membrane • trans-Golgi network membrane • membrane Biological process • positive regulation of canonical Wnt signaling pathway • hair follicle development • inner ear development • G-protein coupled receptor signaling pathway • epithelial cell proliferation involved in renal tubule morphogenesis • regulation of cell proliferation • oocyte differentiation • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8549	14160
Ensembl	ENSG00000139292	ENSMUSG00000020140
UniProt	O75473	Q9Z1P4
RefSeq (mRNA)	NM_001277226 NM_001277227 NM_003667	NM_010195
RefSeq (protein)	NP_001264155 NP_001264156 NP_003658	NP_034325
Location (UCSC)	Chr 12: 71.44 – 71.59 Mb	Chr 10: 115.45 – 115.59 Mb
PubMed search

4BSR, 4BSS, 4BST, 4BSU, 4KNG, 4UFR, 4UFS

8549

14160

ENSG00000139292

ENSMUSG00000020140

O75473

Q9Z1P4

NM_001277226
NM_001277227
NM_003667

NM_010195

NP_001264155
NP_001264156
NP_003658

NP_034325

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G-protein coupled receptor 67 (GPR67) is a protein that in humans is encoded by the LGR5 gene. It is a member of GPCR class A receptor proteins. R-spondin proteins are the biological ligands of LGR5. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues.

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Wikipedia