LGMN

LGMN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N6N, 4N6O, 4FGU, 4AWB, 4AWA, 4AW9
Identifiers
Aliases	LGMN, AEP, LGMN1, PRSC1, legumain
External IDs	MGI: 1330838 HomoloGene: 38075 GeneCards: LGMN
Gene ontology Molecular function • cysteine-type peptidase activity • peptidase activity • hydrolase activity • cysteine-type endopeptidase activity Cellular component • late endosome • apical part of cell • lysosomal lumen • lysosome • extracellular exosome • endolysosome lumen Biological process • negative regulation of neuron apoptotic process • negative regulation of ERBB signaling pathway • renal system process • antigen processing and presentation of exogenous peptide antigen via MHC class II • vitamin D metabolic process • negative regulation of multicellular organism growth • vacuolar protein processing • receptor catabolic process • proteolysis • toll-like receptor signaling pathway • proteolysis involved in cellular protein catabolic process • response to acidic pH Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5641	19141
Ensembl	ENSG00000100600	ENSMUSG00000021190
UniProt	Q99538	O89017
RefSeq (mRNA)	NM_001008530 NM_005606	NM_011175
RefSeq (protein)	NP_001008530 NP_005597	NP_035305.1 NP_035305
Location (UCSC)	Chr 14: 92.7 – 92.75 Mb	Chr 12: 102.39 – 102.44 Mb
PubMed search

4N6N, 4N6O, 4FGU, 4AWB, 4AWA, 4AW9

5641

19141

ENSG00000100600

ENSMUSG00000021190

Q99538

O89017

NM_001008530
NM_005606

NM_011175

NP_001008530
NP_005597

NP_035305.1
NP_035305

Legumain is a protein that in humans is encoded by the LGMN gene.

This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

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