LEKTI

SPINK5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H0Z, 1HDL, 1UUC, 1UVF, 1UVG
Identifiers
Aliases	SPINK5, LEKTI, LETKI, NETS, NS, VAKTI, serine peptidase inhibitor, Kazal type 5
External IDs	MGI: 1919682 HomoloGene: 4987 GeneCards: SPINK5
Gene ontology Molecular function • peptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • cytoplasm • cytosol • endoplasmic reticulum membrane • cell cortex • endoplasmic reticulum • perinuclear region of cytoplasm • epidermal lamellar body • extracellular exosome • extracellular region • intracellular membrane-bounded organelle Biological process • epidermal cell differentiation • negative regulation of proteolysis • negative regulation of serine-type peptidase activity • negative regulation of peptidase activity • epithelial cell differentiation • hair cell differentiation • anagen • extracellular matrix organization • negative regulation of antibacterial peptide production • negative regulation of immune response • regulation of cell adhesion • negative regulation of angiogenesis • negative regulation of serine-type endopeptidase activity • regulation of T cell differentiation • cornification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11005	72432
Ensembl	ENSG00000133710	ENSMUSG00000055561
UniProt	Q9NQ38	Q148R4
RefSeq (mRNA)	NM_001127698 NM_001127699 NM_006846	NM_001081180
RefSeq (protein)	NP_001121170 NP_001121171 NP_006837	NP_001074649
Location (UCSC)	Chr 5: 148.03 – 148.14 Mb	Chr 18: 43.96 – 44.02 Mb
PubMed search

1H0Z, 1HDL, 1UUC, 1UVF, 1UVG

11005

72432

ENSG00000133710

ENSMUSG00000055561

Q9NQ38

Q148R4

NM_001127698
NM_001127699
NM_006846

NM_001081180

NP_001121170
NP_001121171
NP_006837

NP_001074649

Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene.

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Wikipedia