LEFTY2

LEFTY2
Identifiers
Aliases	LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2
External IDs	MGI: 2443573 HomoloGene: 2434 GeneCards: LEFTY2
Gene ontology Molecular function • transforming growth factor beta receptor binding • cytokine activity • growth factor activity Cellular component • extracellular matrix • extracellular region • platelet alpha granule lumen • extracellular space Biological process • multicellular organism development • regulation of apoptotic process • positive regulation of pathway-restricted SMAD protein phosphorylation • cell growth • platelet degranulation • regulation of MAPK cascade • transforming growth factor beta receptor signaling pathway • SMAD protein signal transduction • cell development • BMP signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7044	320202
Ensembl	ENSG00000143768	ENSMUSG00000066652
UniProt	O00292	P57785
RefSeq (mRNA)	NM_001172425 NM_003240	NM_177099
RefSeq (protein)	NP_001165896 NP_003231	NP_796073.1 NP_796073
Location (UCSC)	Chr 1: 225.94 – 225.94 Mb	Chr 1: 180.89 – 180.9 Mb
PubMed search

7044

320202

ENSG00000143768

ENSMUSG00000066652

O00292

P57785

NM_001172425
NM_003240

NM_177099

NP_001165896
NP_003231

NP_796073.1
NP_796073

Left-right determination factor 2 is a protein that in humans is encoded by the LEFTY2 gene.

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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