LAG3

Identifiers

LAG3, CD223, lymphocyte activating 3

External IDs

MGI: 106588 HomoloGene: 1719 GeneCards: LAG3

Gene ontology
Molecular function	• antigen binding • transmembrane signaling receptor activity • MHC class II protein binding
Cellular component	• membrane • external side of plasma membrane • integral component of membrane • plasma membrane
Biological process	• negative regulation of T cell activation • negative regulation of interleukin-2 biosynthetic process • cell surface receptor signaling pathway • positive regulation of natural killer cell mediated cytotoxicity • antigen processing and presentation of exogenous peptide antigen via MHC class II
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3902


16768

Ensembl


ENSG00000089692


ENSMUSG00000030124

UniProt


P18627


Q61790

RefSeq (mRNA)


NM_002286


NM_008479

RefSeq (protein)


NP_002277


NP_032505

Location (UCSC)

Chr 12: 6.77 – 6.78 Mb

Chr 6: 124.9 – 124.91 Mb

PubMed search

Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. In soluble form it is also being developed as a cancer drug in its own right.

The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene

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Wikipedia