L1 (protein)

L1CAM
Identifiers
Aliases	L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1, L1 cell adhesion molecule
External IDs	MGI: 96721 HomoloGene: 20128 GeneCards: L1CAM
Gene ontology Molecular function • protein binding • protein domain specific binding Cellular component • cell projection • growth cone • membrane • focal adhesion • cell surface • integral component of membrane • axonal growth cone • plasma membrane • axon • dendrite • neuronal cell body Biological process • multicellular organism development • nervous system development • positive regulation of axon extension • cell differentiation • leukocyte migration • cell adhesion • chemotaxis • cell-matrix adhesion • axon guidance • cell migration • neuron projection development • synapse organization • axon development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3897	16728
Ensembl	ENSG00000198910	ENSMUSG00000031391
UniProt	P32004	P11627
RefSeq (mRNA)	NM_024003 NM_000425 NM_001143963 NM_001278116	NM_008478
RefSeq (protein)	NP_000416 NP_001137435 NP_001265045 NP_076493	n/a
Location (UCSC)	Chr X: 153.86 – 153.91 Mb	Chr X: 73.85 – 73.9 Mb
PubMed search

3897

16728

ENSG00000198910

ENSMUSG00000031391

P32004

P11627

NM_024003
NM_000425
NM_001143963
NM_001278116

NM_008478

NP_000416
NP_001137435
NP_001265045
NP_076493

n/a

L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. This protein, of 200-220 kDa, is a neuronal cell adhesion molecule with a strong implication in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation. It also plays a key role in treatment-resistant cancers due to its function. It was firstly identified in 1984 by Melitta Schachner who found the protein in post-mitotic mice neurons.

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