Kuragano-shuku (倉賀野宿 Kuragano-shuku?) was the twelfth of the sixty-nine stations of the Nakasendō. It is located in the present-day city of Takasaki, Gunma Prefecture, Japan.
Kuragano-shuku was an intersection between the Nakasendō and the Nikkō Reiheishi Kaidō. Travelers coming from Kyoto would use this route to get to . (If they were coming from Edo, they would have used the Nikkō Kaidō.) During the Edo period, it was a popular port for trader ships on the Karasu River.
Coordinates: 36°17′48″N 139°02′52″E / 36.2966°N 139.0477°E