Kisspeptin

KISS1
Identifiers
Aliases	KISS1, HH13, KiSS-1, KiSS-1 metastasis-suppressor
External IDs	OMIM: 603286 MGI: 2663985 HomoloGene: 1701 GeneCards: KISS1
Gene ontology Molecular function • kisspeptin receptor binding • protein binding Cellular component • extracellular region • apical plasma membrane • cytoplasm • neuronal cell body • neuron projection • extracellular space Biological process • negative regulation of cell proliferation • positive regulation of synaptic transmission • positive regulation of MAPK cascade • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • positive regulation of luteinizing hormone secretion • positive regulation of cytosolic calcium ion concentration • positive regulation of growth hormone secretion • cytoskeleton organization • generation of ovulation cycle rhythm • G-protein coupled receptor signaling pathway • decidualization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3814	280287
Ensembl	ENSG00000170498	ENSMUSG00000102367
UniProt	Q15726	Q6Y4S4
RefSeq (mRNA)	NM_002256	NM_178260
RefSeq (protein)	NP_002247	NP_839991.2 NP_839991
Location (UCSC)	Chr 1: 204.19 – 204.2 Mb	Chr 1: 133.31 – 133.33 Mb
PubMed search

3814

280287

ENSG00000170498

ENSMUSG00000102367

Q15726

Q6Y4S4

NM_002256

NM_178260

NP_002247

NP_839991.2
NP_839991

Kisspeptin (formerly known as metastin) is a protein that is encoded by the KISS1 gene in humans. Kisspeptin is a G-protein coupled receptor ligand for GPR54.Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty, the extent of which is an area of ongoing research. Gonadotropin-releasing hormone is released from the hypothalamus to act on the anterior pituitary triggering the release of luteinizing hormone (LH), and follicle stimulating hormone (FSH). These gonadotropic hormones lead to sexual maturation and gametogenesis. Disrupting GPR54 signaling can cause hypogonadotrophic hypogonadism in rodents and man. The Kiss1 gene is located on chromosome 1. It is transcribed in the brain, adrenal gland, and pancreas.

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