Keratin 5

KRT5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TNU
Identifiers
Aliases	KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A, keratin 5
External IDs	OMIM: 148040 MGI: 96702 HomoloGene: 55461 GeneCards: KRT5
Genetically Related Diseases
Gene ontology Molecular function • scaffold protein binding • structural constituent of cytoskeleton • protein binding • structural molecule activity Cellular component • cytoplasm • cytosol • plasma membrane • keratin filament • extracellular exosome • intermediate filament • membrane • mitochondrion • nucleus Biological process • hemidesmosome assembly • epidermis development • cytoskeleton organization • keratinization • cornification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3852	110308
Ensembl	ENSG00000186081	ENSMUSG00000061527
UniProt	P13647	Q922U2
RefSeq (mRNA)	NM_000424	NM_027011
RefSeq (protein)	NP_000415	NP_081287.1 NP_081287
Location (UCSC)	Chr 12: 52.51 – 52.52 Mb	Chr 15: 101.71 – 101.71 Mb
PubMed search

3TNU

3852

110308

ENSG00000186081

ENSMUSG00000061527

P13647

Q922U2

NM_000424

NM_027011

NP_000415

NP_081287.1
NP_081287

Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells. This protein is involved in several diseases including epidermolysis bullosa simplex and breast and lung cancers.

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Wikipedia