Kaikhosro (Georgian: ქაიხოსრო მუხრანბატონი, K'aikhosro Mukhranbatoni; died 3 October 1629) was a Georgian tavadi ("prince") of the House of Mukhrani, a collateral branch of the royal Bagrationi dynasty of Kartli. He was Prince (Mukhranbatoni) of Mukhrani, ex officio commander of the Banner of Shida Kartli, and regent of Kartli from 1625 to 1626. During the civil war in 1626, Kaikhosro sided with Giorgi Saakadze against Teimuraz I of Kakheti and followed him into exile in the Ottoman Empire, where they both, after three years of military service, were accused of treason and put to death.
Kaikhosro was a son of Vakhtang I, and a younger brother of Teimuraz I, on whose death at the battle of Marabda against Safavid Iran he succeeded to the fief of Mukhrani in 1625. Kaikhosro was allied with the warlord Giorgi Saakadze, who helped him to become regent of Kartli during the anti-Iranian rebellion to the chagrin of his rival Zurab, Duke of Aragvi. Zurab, suspicious of the tandem's designs and inclined to believe that his brother Giorgi, who was married to Kaikhosro's daughter, was part of a plot against him, had Giorgi blinded and made an alliance with Teimuraz I of Kakheti, whom Saakadze tried to prevent from acceding to the throne of Kartli.