KLF9

Identifiers

KLF9, BTEB, BTEB1, Kruppel-like factor 9, Kruppel like factor 9

External IDs

MGI: 1333856 HomoloGene: 931 GeneCards: KLF9

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • DNA binding • metal ion binding • nucleic acid binding
Cellular component	• plasma membrane • nucleus • nucleoplasm • cytosol
Biological process	• regulation of transcription from RNA polymerase II promoter • cellular response to cortisol stimulus • regulation of transcription, DNA-templated • circadian rhythm • negative regulation of keratinocyte proliferation • transcription, DNA-templated • cellular response to thyroid hormone stimulus • rhythmic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


687


16601

Ensembl


ENSG00000119138


ENSMUSG00000033863

UniProt


Q13886


O35739 Q8CEC4

RefSeq (mRNA)


NM_001206


NM_010638

RefSeq (protein)


NP_001197


NP_034768

Location (UCSC)

Chr 9: 70.38 – 70.41 Mb

Chr 19: 23.14 – 23.17 Mb

PubMed search

Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene. Previously known as Basic Transcription Element Binding Protein 1 (BTEB Protein 1), Klf9 is part of the Sp1 C2H2-type zinc finger family of transcription factors. Several previous studies showed Klf9-related regulation of animal development, including cell differentiation of B cells, keratinocytes, and neurons. Klf9 is also a key transcriptional regulator for uterine endometrial cell proliferation, adhesion, and differentiation, all factors that are essential during the process of pregnancy and are turned off during tumorigenesis.

The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription.

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Wikipedia