KLF6

KLF6
Identifiers
Aliases	KLF6, BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9, Kruppel-like factor 6, Kruppel like factor 6
External IDs	MGI: 1346318 HomoloGene: 996 GeneCards: KLF6
Gene ontology Molecular function • DNA binding • protein binding • metal ion binding • nucleic acid binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component • fibrillar center • nucleus • nucleolus • cytosol • intracellular membrane-bounded organelle Biological process • positive regulation of transcription, DNA-templated • B cell differentiation • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1316	23849
Ensembl	ENSG00000067082	ENSMUSG00000000078
UniProt	Q99612	O08584 Q8BPQ2
RefSeq (mRNA)	NM_001008490 NM_001160124 NM_001160125 NM_001300	NM_011803
RefSeq (protein)	NP_001153596 NP_001153597 NP_001291	NP_035933
Location (UCSC)	Chr 10: 3.78 – 3.79 Mb	Chr 13: 5.86 – 5.87 Mb
PubMed search

1316

23849

ENSG00000067082

ENSMUSG00000000078

Q99612

O08584
Q8BPQ2

NM_001008490
NM_001160124
NM_001160125
NM_001300

NM_011803

NP_001153596
NP_001153597
NP_001291

NP_035933

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.

It is a tumor suppressor gene.

This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.

...
Wikipedia