KLF5

KLF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBT
Identifiers
Aliases	KLF5, BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5
External IDs	MGI: 1338056 HomoloGene: 37520 GeneCards: KLF5
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • nucleic acid binding • sequence-specific DNA binding • transcription factor binding Cellular component • Golgi apparatus • intracellular membrane-bounded organelle • nucleoplasm • nucleus Biological process • regulation of microvillus assembly • microvillus assembly • regulation of transcription, DNA-templated • intestinal epithelial cell development • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • angiogenesis • skeletal muscle cell differentiation • positive regulation of fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • cellular response to organic cyclic compound • positive regulation of cell proliferation • cellular response to peptide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	688	12224
Ensembl	ENSG00000102554	ENSMUSG00000005148
UniProt	Q13887	Q9Z0Z7
RefSeq (mRNA)	NM_001730 NM_001286818	NM_009769
RefSeq (protein)	NP_001273747 NP_001721	NP_033899.2 NP_033899
Location (UCSC)	Chr 13: 73.05 – 73.08 Mb	Chr 14: 99.3 – 99.31 Mb
PubMed search

2EBT

688

12224

ENSG00000102554

ENSMUSG00000005148

Q13887

Q9Z0Z7

NM_001730
NM_001286818

NM_009769

NP_001273747
NP_001721

NP_033899.2
NP_033899

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.

KLF5 has been shown to interact with Protein SET.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

...
Wikipedia