KLF12

KLF12
Identifiers
Aliases	KLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDs	MGI: 1333796 HomoloGene: 21417 GeneCards: KLF12
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription corepressor activity • metal ion binding • nucleic acid binding Cellular component • nucleus • nucleoplasm • cytosol Biological process • regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • GO:0006350 transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11278	16597
Ensembl	ENSG00000118922	ENSMUSG00000072294
UniProt	Q9Y4X4	O35738
RefSeq (mRNA)	NM_007249 NM_016285	NM_010636
RefSeq (protein)	NP_009180	NP_034766.2 NP_034766
Location (UCSC)	Chr 13: 73.69 – 74 Mb	Chr 14: 99.87 – 100.15 Mb
PubMed search

11278

16597

ENSG00000118922

ENSMUSG00000072294

Q9Y4X4

O35738

NM_007249
NM_016285

NM_010636

NP_009180

NP_034766.2
NP_034766

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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