KLF1

KLF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L2I, 2MBH, 2N23
Identifiers
Aliases	KLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1
External IDs	MGI: 1342771 HomoloGene: 4785 GeneCards: KLF1
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • DNA binding • core promoter proximal region sequence-specific DNA binding • metal ion binding • nucleic acid binding Cellular component • nuclear chromatin • nucleus Biological process • positive regulation of transcription, DNA-templated • erythrocyte differentiation • cellular response to peptide • regulation of transcription, DNA-templated • transcription, DNA-templated • maternal process involved in female pregnancy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10661	16596
Ensembl	ENSG00000105610	ENSMUSG00000054191
UniProt	Q13351	P46099
RefSeq (mRNA)	NM_006563	NM_010635
RefSeq (protein)	NP_006554	NP_034765
Location (UCSC)	Chr 19: 12.88 – 12.89 Mb	Chr 8: 84.9 – 84.91 Mb
PubMed search

2L2I, 2MBH, 2N23

10661

16596

ENSG00000105610

ENSMUSG00000054191

Q13351

P46099

NM_006563

NM_010635

NP_006554

NP_034765

Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 and on mouse chromosome 8. Krueppel-like factor 1 is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells.

The molecule has two domains; the transactivation domain and the chromatin-remodeling domain. The carboxyl (C) terminal is composed of three C2H2 zinc fingers that binds to DNA, and the amino (N) terminus is proline rich and acidic.

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