KCNN4

KCNN4
Identifiers
Aliases	KCNN4, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4, IK, DHS2, potassium calcium-activated channel subfamily N member 4
External IDs	MGI: 1277957 HomoloGene: 1696 GeneCards: KCNN4
Targeted by Drug
chlorzoxazone, riluzole, clotrimazole, nitrendipine, senicapoc
Gene ontology Molecular function • protein binding • protein phosphatase binding • calcium-activated potassium channel activity • potassium channel activity • calmodulin binding • small conductance calcium-activated potassium channel activity Cellular component • integral component of membrane • membrane • voltage-gated potassium channel complex • plasma membrane • vesicle • neuronal cell body Biological process • calcium ion transport • positive regulation of protein secretion • cell volume homeostasis • potassium ion transport • saliva secretion • ion transport • positive regulation of T cell receptor signaling pathway • transport • immune system process • defense response • phospholipid translocation • stabilization of membrane potential • potassium ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3783	16534
Ensembl	ENSG00000104783	ENSMUSG00000054342
UniProt	O15554	O89109
RefSeq (mRNA)	NM_002250	NM_001163510 NM_008433
RefSeq (protein)	NP_002241	NP_001156982.1 NP_032459.3 NP_001156982 NP_032459
Location (UCSC)	Chr 19: 43.77 – 43.78 Mb	Chr 7: 24.37 – 24.39 Mb
PubMed search

3783

16534

ENSG00000104783

ENSMUSG00000054342

O15554

O89109

NM_002250

NM_001163510
NM_008433

NP_002241

NP_001156982.1
NP_032459.3
NP_001156982
NP_032459

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the K_Ca3.1 protein.

The K_Ca3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

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Wikipedia