KCNJ8

KCNJ8
Identifiers
Aliases	KCNJ8, KIR6.1, uKATP-1, potassium voltage-gated channel subfamily J member 8
External IDs	MGI: 1100508 HomoloGene: 3654 GeneCards: KCNJ8
Gene location (Human) Chr. Chromosome 12 (human) Band 12p12.1 Start 21,764,955 bp End 21,775,581 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 G2|6 74.31 cM Start 142,564,837 bp End 142,571,614 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • voltage-gated ion channel activity • sulfonylurea receptor binding • ATP binding • inward rectifier potassium channel activity • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • ATP-activated inward rectifier potassium channel activity Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle • voltage-gated potassium channel complex • plasma membrane • myofibril • mitochondrion • ATP-sensitive potassium channel complex • sarcolemma Biological process • response to exogenous dsRNA • kidney development • regulation of ion transmembrane transport • vasodilation • ion transport • heart development • response to lipopolysaccharide • defense response to virus • response to pH • potassium ion transport • membrane repolarization during ventricular cardiac muscle cell action potential • potassium ion import across plasma membrane • potassium ion import • transport • potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3764	16523
Ensembl	ENSG00000121361	ENSMUSG00000030247
UniProt	Q15842	P97794
RefSeq (mRNA)	NM_004982	NM_008428 NM_001330363 NM_001330366
RefSeq (protein)	NP_004973	NP_001317292 NP_001317295 NP_032454
Location (UCSC)	Chr 12: 21.76 – 21.78 Mb	Chr 12: 142.56 – 142.57 Mb
PubMed search

3764

16523

ENSG00000121361

ENSMUSG00000030247

Q15842

P97794

NM_004982

NM_008428
NM_001330363
NM_001330366

NP_004973

NP_001317292
NP_001317295
NP_032454

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein. A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir6.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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