KCNJ5

KCNJ5
Identifiers
Aliases	KCNJ5, CIR, GIRK4, KATP1, KIR3.4, LQT13, potassium voltage-gated channel subfamily J member 5
External IDs	MGI: 104755 HomoloGene: 20248 GeneCards: KCNJ5
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.3 Start 128,891,356 bp End 128,921,035 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A4|9 17.65 cM Start 32,314,707 bp End 32,344,350 bp
Gene ontology Molecular function • G-protein activated inward rectifier potassium channel activity • protein binding • inward rectifier potassium channel activity • voltage-gated ion channel activity • voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Cellular component • integral component of membrane • T-tubule • plasma membrane • membrane • external side of plasma membrane • voltage-gated potassium channel complex Biological process • potassium ion transport • regulation of ion transmembrane transport • ion transport • regulation of heart rate by cardiac conduction • membrane repolarization during atrial cardiac muscle cell action potential • membrane repolarization during ventricular cardiac muscle cell action potential • ventricular cardiac muscle cell membrane repolarization • potassium ion import across plasma membrane • potassium ion import • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3762	16521
Ensembl	ENSG00000120457	ENSMUSG00000032034
UniProt	P48544	P48545
RefSeq (mRNA)	NM_000890 NM_001354169	NM_010605
RefSeq (protein)	NP_000881 NP_001341098	NP_034735
Location (UCSC)	Chr 11: 128.89 – 128.92 Mb	Chr 11: 32.31 – 32.34 Mb
PubMed search

3762

16521

ENSG00000120457

ENSMUSG00000032034

P48544

P48545

NM_000890
NM_001354169

NM_010605

NP_000881
NP_001341098

NP_034735

G protein-activated inward rectifier potassium channel 4 is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with other G-protein-activated potassium channel subunits to form a heterotetrameric pore-forming complex.

Mutations in KCNJ5/Kir3.4 cause Andersen-Tawil syndrome .

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Wikipedia