KCNH5

KCNH5
Identifiers
Aliases	KCNH5, EAG2, H-EAG2, Kv10.2, hEAG2, potassium voltage-gated channel subfamily H member 5
External IDs	MGI: 3584508 HomoloGene: 15858 GeneCards: KCNH5
Genetically Related Diseases
major depressive disorder
Targeted by Drug
quinidine
Gene ontology Molecular function • potassium channel activity • ion channel binding • voltage-gated ion channel activity • calmodulin binding • ion channel activity • protein heterodimerization activity • voltage-gated potassium channel activity • phosphorelay sensor kinase activity Cellular component • integral component of membrane • membrane • plasma membrane • intracellular • cell surface • integral component of plasma membrane Biological process • regulation of G2/M transition of mitotic cell cycle • signal transduction by protein phosphorylation • regulation of membrane potential • regulation of ion transmembrane transport • ion transport • potassium ion transport • transmembrane transport • potassium ion transmembrane transport • transport • phosphorelay signal transduction system Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27133	238271
Ensembl	ENSG00000140015	ENSMUSG00000034402
UniProt	Q8NCM2	Q920E3
RefSeq (mRNA)	NM_139318 NM_172375 NM_172376	NM_172805
RefSeq (protein)	NP_647479 NP_758963	NP_766393.2 NP_766393
Location (UCSC)	Chr 14: 62.7 – 63.1 Mb	Chr 12: 74.9 – 75.18 Mb
PubMed search

27133

238271

ENSG00000140015

ENSMUSG00000034402

Q8NCM2

Q920E3

NM_139318
NM_172375
NM_172376

NM_172805

NP_647479
NP_758963

NP_766393.2
NP_766393

Potassium voltage-gated channel, subfamily H (eag-related), member 5, also known as KCNH5, is a human gene encoding the K_v10.2 protein.

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. This gene is not expressed in differentiating myoblasts. Alternative splicing results in three transcript variants encoding distinct isoforms.

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Wikipedia