KCNH2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA, 2N7G

Identifiers

Aliases

KCNH2, ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1, potassium voltage-gated channel subfamily H member 2

External IDs

MGI: 1341722 HomoloGene: 201 GeneCards: KCNH2

Targeted by Drug

rottlerin, disopyramide, dofetilide, astemizole, E4031, ibutilide, terfenadine

Gene ontology
Molecular function	• potassium channel activity • protein homodimerization activity • scaffold protein binding • voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization • C3HC4-type RING finger domain binding • voltage-gated ion channel activity • ion channel activity • protein binding • identical protein binding • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • voltage-gated potassium channel activity • phosphorelay sensor kinase activity • inward rectifier potassium channel activity • ubiquitin protein ligase binding • delayed rectifier potassium channel activity
Cellular component	• integral component of membrane • membrane • voltage-gated potassium channel complex • plasma membrane • cell surface • perinuclear region of cytoplasm
Biological process	• membrane depolarization during action potential • cardiac muscle contraction • potassium ion export • signal transduction by protein phosphorylation • regulation of membrane potential • regulation of ion transmembrane transport • ventricular cardiac muscle cell action potential • ion transport • potassium ion export across plasma membrane • potassium ion transport • cellular response to drug • membrane repolarization during action potential • cardiac conduction • potassium ion homeostasis • negative regulation of potassium ion export • regulation of heart rate by hormone • transmembrane transport • potassium ion transmembrane transport • positive regulation of potassium ion transmembrane transport • transport • phosphorelay signal transduction system • regulation of membrane repolarization • negative regulation of potassium ion transmembrane transport • membrane repolarization during cardiac muscle cell action potential • regulation of heart rate by cardiac conduction • regulation of potassium ion transmembrane transport • regulation of ventricular cardiac muscle cell membrane repolarization • membrane repolarization during ventricular cardiac muscle cell action potential
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3757


16511

Ensembl


ENSG00000055118


ENSMUSG00000038319

UniProt


Q12809


O35219

RefSeq (mRNA)


NM_000238 NM_001204798 NM_172056 NM_172057


NM_001294162 NM_013569

RefSeq (protein)


NP_000229 NP_001191727 NP_742053 NP_742054


NP_001281091.1 NP_001281091 NP_038597

Location (UCSC)

Chr 7: 150.94 – 150.98 Mb

Chr 5: 24.32 – 24.35 Mb

PubMed search

1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA, 2N7G

NM_000238
NM_001204798
NM_172056
NM_172057

NM_001294162
NM_013569

NP_000229
NP_001191727
NP_742053
NP_742054

...
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