KCNE2

KCNE2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M0Q
Identifiers
Aliases	KCNE2, ATFB4, LQT5, LQT6, MIRP1, potassium voltage-gated channel subfamily E regulatory subunit 2
External IDs	OMIM: 603796 MGI: 1891123 HomoloGene: 71688 GeneCards: KCNE2
Gene ontology Molecular function • potassium channel activity • protein homodimerization activity • ion channel binding • delayed rectifier potassium channel activity • voltage-gated ion channel activity • potassium channel regulator activity • protein binding • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • voltage-gated potassium channel activity • inward rectifier potassium channel activity Cellular component • integral component of membrane • membrane • voltage-gated potassium channel complex • plasma membrane • cell surface • lysosome Biological process • negative regulation of voltage-gated potassium channel activity • tongue development • potassium ion export • regulation of inward rectifier potassium channel activity • positive regulation of voltage-gated calcium channel activity • regulation of ion transmembrane transport • ventricular cardiac muscle cell action potential • aging • cardiac muscle cell action potential involved in contraction • ion transport • potassium ion transport • membrane repolarization • cellular response to drug • membrane repolarization during action potential • regulation of delayed rectifier potassium channel activity • cardiac conduction • potassium ion import • potassium ion transmembrane transport • transport • regulation of membrane repolarization • positive regulation of proteasomal protein catabolic process • regulation of heart rate by cardiac conduction • regulation of potassium ion transmembrane transport • regulation of cyclic nucleotide-gated ion channel activity • negative regulation of delayed rectifier potassium channel activity • regulation of ventricular cardiac muscle cell membrane repolarization • membrane repolarization during ventricular cardiac muscle cell action potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9992	246133
Ensembl	ENSG00000159197	ENSMUSG00000039672
UniProt	Q9Y6J6	Q9D808
RefSeq (mRNA)	NM_172201	NM_134110
RefSeq (protein)	NP_751951	NP_598871.1 NP_598871
Location (UCSC)	Chr 21: 34.36 – 34.37 Mb	Chr 16: 92.29 – 92.3 Mb
PubMed search

2M0Q

9992

246133

ENSG00000159197

ENSMUSG00000039672

Q9Y6J6

Q9D808

NM_172201

NM_134110

NP_751951

NP_598871.1
NP_598871

Potassium voltage-gated channel subfamily E member 2 (KCNE2), also known as MinK-related peptide 1 (MiRP1), is a protein that in humans is encoded by the KCNE2 gene on chromosome 21. MiRP1 is a voltage-gated potassium channel accessory subunit (beta subunit) associated with Long QT syndrome. It is ubiquitously expressed in many tissues and cell types. Because of this and its ability to regulate multiple different ion channels, KCNE2 exerts considerable influence on a number of cell types and tissues. Human KCNE2 is a member of the five-strong family of human KCNE genes. KCNE proteins contain a single membrane-spanning region, extracellular N-terminal and intracellular C-terminal. KCNE proteins have been widely studied for their roles in the heart and in genetic predisposition to inherited cardiac arrhythmias. The KCNE2 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. More recently, roles for KCNE proteins in a variety of non-cardiac tissues have also been explored.

...
Wikipedia