KCNE1

KCNE1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2K21
Identifiers
Aliases	KCNE1, ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK, potassium voltage-gated channel subfamily E regulatory subunit 1
External IDs	OMIM: 176261 HomoloGene: 185 GeneCards: KCNE1
Gene ontology Molecular function • potassium channel activity • delayed rectifier potassium channel activity • voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization • voltage-gated ion channel activity • telethonin binding • potassium channel regulator activity • protein binding • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • voltage-gated potassium channel activity Cellular component • membrane • integral component of membrane • voltage-gated potassium channel complex • plasma membrane • cell surface • Z disc • apical plasma membrane • membrane raft • lysosome Biological process • potassium ion export • regulation of ion transmembrane transport • protein O-linked glycosylation • ventricular cardiac muscle cell action potential • cardiac muscle cell action potential involved in contraction • ion transport • sensory perception of sound • potassium ion transport • membrane repolarization • negative regulation of protein targeting to membrane • membrane repolarization during action potential • regulation of delayed rectifier potassium channel activity • cardiac conduction • potassium ion transmembrane transport • transport • positive regulation of potassium ion transmembrane transport • protein N-linked glycosylation • membrane repolarization during cardiac muscle cell action potential • regulation of heart rate by cardiac conduction • regulation of potassium ion transmembrane transport • negative regulation of delayed rectifier potassium channel activity • cellular response to cAMP • regulation of ventricular cardiac muscle cell membrane repolarization • membrane repolarization during ventricular cardiac muscle cell action potential Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3753	n/a
Ensembl	n/a	n/a
UniProt	P15382 Q6FHJ6	n/a
RefSeq (mRNA)	NM_000219 NM_001127668 NM_001127669 NM_001127670 NM_001270402 NM_001270403 NM_001270404 NM_001270405	n/a
RefSeq (protein)	NP_000210 NP_001121140 NP_001121141 NP_001121142 NP_001257331 NP_001257332 NP_001257333 NP_001257334 NP_000210.2	n/a
Location (UCSC)	Chr 21: 34.42 – 34.42 Mb	n/a
PubMed search		n/a

2K21

3753

n/a

n/a

n/a

P15382
Q6FHJ6

n/a

NM_001270403
NM_001270404
NM_001270405

n/a

NP_001257332
NP_001257333
NP_001257334
NP_000210.2

n/a

Potassium voltage-gated channel subfamily E member 1 is a protein that in humans is encoded by the KCNE1 gene.

Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.

KCNE1 is one of five members of the KCNE family of Kv channel ancillary or β subunits. It is also known as minK (minimal potassium channel subunit).

KCNE1 is primarily known for modulating the cardiac and epithelial Kv channel α subunit, KCNQ1. KCNQ1 and KCNE1 form a complex in human ventricular cardiomyocytes that generates the slowly activating K+ current, IKs. Together with the rapidly activating K+ current (IKr), IKs is important for human ventricular repolarization. KCNQ1 is also essential for the normal function of many different epithelial tissues, but in these non-excitable cells it is thought to be predominantly regulated by KCNE2 or KCNE3.

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Wikipedia