KCNC2

KCNC2
Identifiers
Aliases	KCNC2, KV3.2, potassium voltage-gated channel subfamily C member 2
External IDs	MGI: 96668 HomoloGene: 71199 GeneCards: KCNC2
Gene location (Human) Chr. Chromosome 12 (human) Band No data available Start 75,040,077 bp End 75,209,868 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band No data available Start 112,271,121 bp End 112,467,024 bp
Gene ontology Molecular function • potassium channel activity • ion channel binding • voltage-gated ion channel activity • ion channel activity • voltage-gated potassium channel activity • delayed rectifier potassium channel activity Cellular component • integral component of membrane • vesicle • perikaryon • postsynaptic membrane • cell projection • membrane • voltage-gated potassium channel complex • plasma membrane • synapse • integral component of plasma membrane • intracellular • neuronal cell body membrane • axon • cell junction • terminal bouton • neuronal cell body • dendrite • basolateral plasma membrane • apical plasma membrane • axolemma • neuron projection • presynaptic membrane Biological process • response to organic cyclic compound • protein heterooligomerization • regulation of insulin secretion • response to nerve growth factor • regulation of ion transmembrane transport • cellular response to toxic substance • response to magnesium ion • ion transport • globus pallidus development • nitric oxide-cGMP-mediated signaling pathway • potassium ion transport • ion transmembrane transport • transmembrane transport • response to amine • positive regulation of potassium ion transmembrane transport • cellular response to nitric oxide • response to light intensity • response to ethanol • protein homooligomerization • response to toxic substance • cellular response to ammonium ion • potassium ion transmembrane transport • positive regulation of voltage-gated potassium channel activity • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3747	268345
Ensembl	ENSG00000166006	ENSMUSG00000035681
UniProt	Q96PR1	Q14B80
RefSeq (mRNA)	NM_001260497 NM_001260498 NM_001260499 NM_139136 NM_139137 NM_153748	NM_001025581
RefSeq (protein)	NP_001247426 NP_001247427 NP_001247428 NP_631874 NP_631875 NP_715624	NP_001020752
Location (UCSC)	Chr 12: 75.04 – 75.21 Mb	Chr 12: 112.27 – 112.47 Mb
PubMed search

3747

268345

ENSG00000166006

ENSMUSG00000035681

Q96PR1

Q14B80

NM_153748

NM_001025581

NP_715624

NP_001020752

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).

K_v3.1 and K_v3.2 channels are prominently expressed in neurons that fire at high frequency. K_v3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.

K_v3.1/K_v3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation. Sometimes in heteromeric complexes with K_v3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.

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Wikipedia