Junctional adhesion molecule

JAM2
Identifiers
Aliases	JAM2, C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM, junctional adhesion molecule 2
External IDs	MGI: 1933820 HomoloGene: 10929 GeneCards: JAM2
Gene ontology Molecular function • protein binding • protein heterodimerization activity Cellular component • integral component of membrane • cell junction • plasma membrane • integral component of plasma membrane • membrane • bicellular tight junction Biological process • single organismal cell-cell adhesion • negative regulation of cell adhesion • extracellular matrix organization • leukocyte migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	58494	67374
Ensembl	ENSG00000154721	ENSMUSG00000053062
UniProt	P57087	Q9JI59
RefSeq (mRNA)	NM_001270407 NM_001270408 NM_021219	NM_023844
RefSeq (protein)	NP_001257336 NP_001257337 NP_067042	NP_076333.3 NP_076333
Location (UCSC)	Chr 21: 25.64 – 25.72 Mb	Chr 16: 84.77 – 84.83 Mb
PubMed search

58494

67374

ENSG00000154721

ENSMUSG00000053062

P57087

Q9JI59

NM_001270407
NM_001270408
NM_021219

NM_023844

NP_001257336
NP_001257337
NP_067042

NP_076333.3
NP_076333

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322 (cluster of differentiation 322).

Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

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Wikipedia