Julius Echter von Mespelbrunn (18 March 1545 – 9 September 1617) was Prince-Bishop of Würzburg from 1573. He was born in Mespelbrunn Castle, Spessart (Lower Franconia) and died in Würzburg.
He was educated in Mainz, Leuven, Douai, Paris, Angers, Pavia, and Rome. In Rome he became a licentiate of canon and civil law. In 1567 he entered on his duties as canon of Würzburg, an office to which he had been appointed in 1554; in 1570 he became the dean of the cathedral chapter, and in 1573, at the age of twenty-eight, even before his ordination to the priesthood, was appointed to the office of the Prince-Bishop of Würzburg.
During the first ten years of Echter's government, the attempt to unite the Abbey of Fulda and the Bishopric of Würzburg, after the deposition of the Prince-Abbot Balthasar von Dernbach, caused much confusion. From the beginning, he carried out a thorough ecclesiastical restoration. To this end, he promoted the Jesuits and their ministry. Echter re-founded the University of Würzburg which was opened 2 January 1582. It became a model for all similar Counter-Reformation institutions. Under the Jesuits it flourished, grew rapidly, and furnished the see with the priests and officials needed to prosecute the Counter-Reformation. The bishop took decisive steps against Protestantism. He banished all Lutheran preachers from his territory and removed all priests who were unwilling to observe the rules of their office. Public officials had to be Catholics, and none but Catholic teachers could be appointed. He began, moreover, courses of careful instruction for non-Catholics, and to some extent threatened them with penalties and even with banishment. Within three years about 100,000 returned to the Catholic Church.