Princess Joséphine-Charlotte of Belgium (Joséphine-Charlotte Stéphanie Ingeborg Elisabeth Marie-José Marguerite Astrid; 11 October 1927 – 10 January 2005), also Grand Duchess Joséphine Charlotte of Luxembourg was Grand Duchess consort of Luxembourg as the wife of Grand Duke Jean. She was a first cousin of Harald V of Norway. She was the first child of King Leopold III of Belgium, and sister of the late King Baudouin and retired King Albert II, and aunt of King Philippe.

Joséphine-Charlotte was born in 1927 at the Royal Palace of Brussels. She was the oldest child and only daughter of the King Leopold III of the Belgians and his first wife, Astrid of Sweden.

Princess Joséphine-Charlotte was christened a month after her birth. Her godfather was her uncle, Prince Charles, Count of Flanders and her godmother was her future mother-in-law, Grand Duchess Charlotte of Luxembourg.

While expecting her daughter, Astrid had read a biography of her ancestress, the French empress Joséphine de Beauharnais. Josephine was also the name of one of the child's great-aunts, Princess Joséphine-Caroline of Belgium, the dearest sister of King Albert I. Astrid was a devoted mother to her "little Jo". The young Princess spent her childhood at the Stuyvenberg Palace just outside Brussels with her parents. She was the sister of Belgian monarchs Baudouin and Albert II.

Joséphine-Charlotte's popular mother was killed in an automobile accident in 1935 at age 29. Joséphine-Charlotte responded courageously to the situation, trying to take care of her younger brothers, Baudouin and Albert.

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