The name Jornada del Muerto is translated loosely from Spanish, historically referring to it as the "Journey of the Dead Man", though the modern literal translation is closer to "The Working Day of the Dead". As a geographic name, "Jornada del Muerto" is the desert region the Conquistadors had to cross to make it from Las Cruces to Socorro, New Mexico. As a name-place, "Jornada del Muerto" is a loose translations of "single day's journey of the dead man" hence "route of the dead man") in the U.S. state of New Mexico was the name given by the Spanish conquistadors to the Jornada del Muerto Desert basin, and the particularly dry 100-mile (160 km) stretch of a route through it.
The trail led northward from central Spanish colonial New Spain, present-day Mexico, to the farthest reaches of the viceroyalty in northern Nuevo México Province (the area around the upper valley of the Rio Grande). The route later became a section of the Camino Real de Tierra Adentro.
The Jornada del Muerto Desert ecoregion, in the Deserts and xeric shrublands Biome, is a wide and long stretch of flat desert landforms and xeric habitat about 100 miles (160 km) from north to south. The desert runs between the Oscura Mountains and San Andres Mountains on the east, and the Fra Cristóbal Range and Caballo Mountains on the west. The western mountains block access to the Rio Grande, the most reliable water source in the region.
The Jornada del Muerto Desert remains almost entirely uninhabited and undeveloped to the present day. Located just to the east of the southernmost region of the desert is the Jornada Basin LTER station, used for study of desert ecology, land management, plant physiology, and related topics.