John Selby Spence (May 19, 1909 – March 7, 1973) was the Roman Catholic titular bishop of Aggersel and auxiliary bishop of the Roman Catholic Archdiocese of Washington.
Born in Baltimore, Maryland, Selby was ordained to the priesthood on December 5, 1933. On March 17, 1964, Selby was appointed bishop and was consecrated on May 19, 1964.