John H. Gaddum
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Sir John Gaddum FRS FRSE |
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| Born | John Henry Gaddum 31 March 1900 Hale, Cheshire |
| Died | 30 June 1965 (aged 65) Cambridge, England |
| Nationality | British |
| Fields | Pharmacology |
| Institutions |
Cairo University University College London Porton Down |
| Alma mater |
Rugby School Trinity College, Cambridge |
| Known for | first scientist to postulate that 5-HT might have a role in mood regulation |
| Notable awards | Fellow of the Royal Society |
Sir John Henry Gaddum FRS FRSE (31 March 1900 – 30 June 1965) was an English pharmacologist who discovered Substance P, a neuropeptide in 1931 along with Ulf von Euler. He was a founder member of the British Pharmacological Society and first editor of the British Journal of Pharmacology.
He was born in Hale (now part of Manchester) the son of silk merchant, Henry Edwin Gaddum and his wife Phyllis Mary Barratt. He was educated at Moorland House School, Heswall, Cheshire; Rugby School; and Trinity College, Cambridge.
He completed his BSc in Physiology at the University of Cambridge in 1922, and his MD at University College London in 1925. His first role was to assist J. W, Trevan at the Wellcome Physiological Research Laboratories.
From 1927–33, Gaddum worked under Henry Dale at the National Institute for Medical Research, and helped develop the classical laws of drug antagonism. He showed that sympathetic nerves release adrenaline. Together with Ulf von Euler, he established the release of acetylcholine in autonomic ganglia.
From 1933 to 1935, Gaddum was professor of pharmacology at the University of Cairo. Subsequent to this he took up a chair at University College London, from 1935 to 1938 and University of London from 1938 to 1942. During the Second World War he advised the War Office on potential use of toxins and biological weapons. He was given the rank of Lt Colonel.
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