John Clayton (1754–1843) was an English Independent minister. He became known for his conservative social views, after the Priestley Riots.
Clayton was born at Wood End Farm, Clayton, near Chorley, Lancashire, 5 October 1764, the only son of George Clayton, a bleacher; he had nine elder sisters. He was educated at Leyland grammar school, and was apprenticed to his brother-in-law, Boultbee, an apothecary in Manchester. At the end of four years he ran off, and made his way to the house of a married sister in London.
Clayton was taken to hear the Rev. William Romaine preach, and a religious conversion followed. Clayton was then introduced to the Countess of Huntingdon, and sent by her to Trevecca College. He became a popular preacher, and was sent to take charge of a chapel at Tunbridge Wells. He also preached frequently in London. In 1777 he sought episcopal ordination, but difficulties arose, and reading Michaijah Towgood's Letters on Dissent made him a nonconformist; the Countess rebuked him in a long letter.
Sir Harry Trelawny, 7th Baronet, minister of a Presbyterian congregation at West Looe in Cornwall, took Clayton on as assistanr. Clayton's Calvinism soon led to a break, and he accepted an invitation to succeed the Rev. Samuel Wilton, D.D., as pastor of the Weigh-house Chapel in London; and he was ordained there 25 November 1778.
In 1793 Clayton was appointed one of the preachers at the merchants' lecture. He held similar posts at Fetter Lane, Holborn, and Hare Court, Aldersgate.
About 1820 Clayton bought a small estate at Gaines in Essex, and in 1826 he resigned the charge of the Weigh-house, after a pastorate of 48 years. His wife died 11 January 1836, and he died 22 September 1843. He is buried in Bunhill Fields.