Joachim Frank
| Joachim Frank | |
|---|---|
| Born | Joachim Frank September 12, 1940 Weidenau/Sieg, Germany |
| Fields | Structural Biology, Cryo-electron Microscopy and Protein Synthesis |
| Institutions | Columbia University College of Physicians and Surgeons, Department of Biochemistry and Molecular Biophysics |
| Alma mater | University of Freiburg |
| Known for | Single-particle cryo-electron microscopy, Ribosome structure and dynamics |
| Notable awards | Benjamin Franklin Medal in Life Science (2014) Wiley Prize in Biomedical Sciences (2017) |
| Spouse | Carol J. Saginaw (m. 1983) |
| Children | 2 |
Joachim Frank (born September 12, 1940 in Weidenau/Sieg) is a German-born biophysicist at Columbia University, New York City. He is regarded as the founder of single-particle cryo-electron microscopy (cryo-EM) and made significant contributions to structure and function of the ribosome from bacteria and eukaryotes.
After completing his Vordiplom (B.S.) degree in Physics at the University of Freiburg (1963) and his Diplom (M.S.) under Walter Rollwagen’s mentorship at the Ludwig Maximilians University of Munich with the thesis “Untersuchung der Sekundärelektronen-Emission von Gold am Schmelzpunkt” (Investigation of secondary electron emission of gold at its melting point) (1967), Frank obtained his Ph.D. from the Technical University of Munich for graduate studies in Walter Hoppe’s lab at the Max Planck Institut für Eiweiss- und Lederforschung (now Max Planck Institut fűr Biochemie) with the dissertation Untersuchungen von elektronenmikroskopischen Aufnahmen hoher Auflösung mit Bilddifferenz- und Rekonstruktionsverfahren (Investigations of high-resolution electron micrographs using image difference and reconstruction methods) (1970). The thesis explores the use of digital image processing and optical diffraction in the analysis of electron micrographs, and alignment of images using the cross-correlation function.
As a Harkness postdoctoral fellow he had the opportunity to study for two years in the United States: with Robert Nathan at the Jet Propulsion Laboratory, California Institute of Technology; with Robert M. Glaeser at Donner Lab, University of California, Berkeley and with Benjamin M. Siegel at Cornell University, Ithaca, New York. In the fall of 1972 he returned briefly to the Max Planck Institute of Biochemistry in Martinsried as research assistant, working on the theory of partial coherence in electron microscopy , then, in 1973, he joined the Cavendish Laboratory, University of Cambridge as Senior Research Assistant under Vernon Ellis Cosslett.
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