Jean Astruc (Sauve, France, 19 March 1684 – Paris, 5 May 1766) was a professor of medicine at Montpellier and Paris, who wrote the first great treatise on syphilis and venereal diseases, and also, with a small anonymously published book, played a fundamental part in the origins of critical textual analysis of works of scripture. Astruc was the first to try to demonstrate, by using the techniques of textual analysis that were commonplace in studying the secular classics, the theory that Genesis was composed based on several sources or manuscript traditions, an approach now called the documentary hypothesis.
The son of a Protestant minister who had converted to Catholicism (although the House of Astruc was of medieval Jewish origin), Astruc was educated at Montpellier, one of the great schools of medicine in early modern Europe. His dissertation and first publication, submitted when he was only 19, is on decomposition, and contains many references to recent research on the lungs by Thomas Willis and Robert Boyle. After teaching medicine at Montpellier he became a member of the medical faculty at the University of Paris. His numerous medical writings, or materials for the history of medical education at Montpellier, are now forgotten, but the work published by him anonymously in 1753 has secured for him a permanent reputation. This book, brought out anonymously in 1753, was entitled Conjectures sur les mémoires originauz dont il paroit que Moyse s'est servi pour composer le livre de la Génèse. Avec des remarques qui appuient ou qui éclaircissent ces conjectures ("Conjectures on the original documents that Moses appears to have used in composing the Book of Genesis. With remarks that support or throw light upon these conjectures"). The title cautiously gives the place of publication as Brussels, safely beyond the reach of French authorities.