Janus kinase 1

JAK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI
Identifiers
Aliases	JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1
External IDs	MGI: 96628 HomoloGene: 1678 GeneCards: JAK1
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • CCR5 chemokine receptor binding • growth hormone receptor binding • metal ion binding • kinase activity • protein binding • protein tyrosine kinase activity • protein phosphatase binding • receptor binding • ATP binding • ubiquitin protein ligase binding • non-membrane spanning protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • membrane • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • cytoskeleton • endomembrane system • nucleus Biological process • cell differentiation • intracellular signal transduction • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • interferon-gamma-mediated signaling pathway • response to antibiotic • MAPK cascade • positive regulation of sprouting angiogenesis • protein phosphorylation • regulation of type I interferon-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • regulation of cell proliferation • type I interferon signaling pathway • interleukin-2-mediated signaling pathway • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • cell migration • innate immune response • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3716	16451
Ensembl	ENSG00000162434	ENSMUSG00000028530
UniProt	P23458	P52332
RefSeq (mRNA)	NM_002227 NM_001320923 NM_001321852 NM_001321853 NM_001321854 NM_001321855 NM_001321856 NM_001321857	NM_146145
RefSeq (protein)	NP_001307852 NP_001308781 NP_001308782 NP_001308783 NP_001308784 NP_001308785 NP_001308786 NP_002218	n/a
Location (UCSC)	Chr 1: 64.83 – 64.97 Mb	Chr 4: 101.15 – 101.27 Mb
PubMed search

3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI

3716

16451

ENSG00000162434

ENSMUSG00000028530

...
Wikipedia