Jám Nizámuddín II (Sindhi: ڄام نظام الدين عرف‎, Urdu: جام نظام الدين ثاني‎; 1439–1509), also known as Jam Nizam al-Din or Jám Nindó (Sindhi: ڄام نندو‎), was the Rajput Sultan of Sindh between 1461 and 1508 CE. He was the most famous ruler of the Samma dynasty, which ruled Sindh, parts of Punjab and Balochistan from 1351 to 1551 CE. His capital was Thatta in modern-day southern Pakistan. The Samma dynasty reached the height of its power during the reign of Nizamuddin, who is still recalled as a hero, and whose rule is considered the golden-age of Sindh.

Nizamuddin's grave is located on Makli Hill and part of the world heritage site of Historical Monuments at Makli. The tomb is an impressive stone structure with fine ornamental carving similar to the 15th-century Gujrat style. It has been restored but unfortunately, it suffers from cracks and wall distortions caused by rough weathering and erosion of the slope on which it stands. After his death, his son Jám Ferózudin lost the Sultanate in 1525 CE to an invading army of Shah Beg Arghun, who had been thrown out of Kandahar by Babur.

Nizamuddín was elected to the throne of the Kingdom by joint councils of men of Thatta, as well as of the military on the 25th of Rabi' al-awwal, 866 (1461 CE), after the death of his father Jam Sanjar. Shortly, after his accession, he went with large force to Bukkur, where he spent about a year, fighting Baloch tribes. He strengthened the fort of Bukkur and left the place in charge of his house-born slave Dilshád, after returning to the capital.

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