JUNB

JUNB
Identifiers
Aliases	JUNB, AP-1, JunB proto-oncogene, AP-1 transcription factor subunit
External IDs	MGI: 96647 HomoloGene: 7390 GeneCards: JUNB
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • transcription factor complex • nucleoplasm • nuclear chromatin • chromatin • nucleus Biological process • cellular response to calcium ion • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • regulation of cell death • osteoclast differentiation • labyrinthine layer blood vessel development • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • regulation of cell cycle • vasculogenesis • embryonic process involved in female pregnancy • response to lipopolysaccharide • decidualization • regulation of cell proliferation • trophectodermal cell differentiation • osteoblast differentiation • positive regulation of cell differentiation • response to radiation • osteoblast proliferation • cellular process • positive regulation of transcription from RNA polymerase II promoter • response to drug • response to cAMP • response to mechanical stimulus • transcription, DNA-templated • cellular response to hormone stimulus • response to cytokine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3726	16477
Ensembl	ENSG00000171223	ENSMUSG00000052837
UniProt	P17275	P09450
RefSeq (mRNA)	NM_002229	NM_008416
RefSeq (protein)	NP_002220	NP_032442.1 NP_032442
Location (UCSC)	Chr 19: 12.79 – 12.79 Mb	Chr 8: 84.97 – 84.98 Mb
PubMed search

3726

16477

ENSG00000171223

ENSMUSG00000052837

P17275

P09450

NM_002229

NM_008416

NP_002220

NP_032442.1
NP_032442

Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

JUNB has been shown to interact with

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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